1,638 research outputs found

    Focus groups of value concepts of producers: National Report Netherlands

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    The Organic Revision project was funded by the EU with the aim of supporting the further development of the EU Regulation 2092/91 on organic production. As part of the project focus groups were run in five European countries on value concepts of organic producers and other stakeholders, during 2004-2005. The project aims to provide an overview of values held among organic stakeholders, and of similarities and differences among the various national and private organic standards. In the Netherlands four focus groups were held, one pre-test with researchers, and three groups with established organic producers both of livestock and horticulture. It was not possible to recruit any newly converted producers to a meeting in the Netherlands. The following conclusions were reached: Summarising the values in the words of the participants of these focus groups, organic agriculture could be defined as follows: "Organic agriculture is about producing endlessly, with care and respect for humans, animals, plants and soil. Organic farmers produce healthy and tasty food without harming the environment or the development of others. Their farms and agriculture in general are inter-connected with small and big world problems." Overall there seem to be many similarities between the groups. Values related to all principles were discussed in all the groups; the differences observed were related to the different backgrounds. The researchers spoke about their own experiences from work but also about their ideas from a consumer’s point of view. For the dairy farmers animal welfare was an important value while soil was more important to the arable farmers. Also with regard to the values nearness and proximity, differences between arable and dairy farmers seemed to reflect their daily practice. Arable farmers are faced with an anonymous market, with high and changing quality standards of the trade, and regard local production and consumption as a solution to their problems. The other groups of farmers also support this quest for another economic system. The researchers mention the unrealistic ideas of consumers concerning organic agriculture and they wonder how to make consumers more aware. The farmers would like to educate the consumer more, also about the relation of production in their country compared with production and development elsewhere. The farmers see the inter-connectedness of agriculture with income and development in developing countries very clearly and for some this was an important argument to convert. The farmers have a great feeling of responsibility for the world (ecologically and socially). For all of them the intentions are more important than the norms. On the basis of the coding, it appears that values in relation to three principles were most important in the discussion. These are the ecology principle, holism and systems approach and professional pride, in order of importance. The following values were mentioned in relation to the principle of ecology: Recycling (the cycle) and saving energy were of major importance and nature conservation or nature integration on the farm was an important aim for some farmers. Co-operation between arable and animal production is seen as a very important means to close the cycle. And in the Netherlands with far going specialisation of farms this is sometimes a real challenge. Conflicts with the economy easily arise but also conflicts with national legislation restrict the farmers in their development. The values itself are not experienced as restricting. All groups except for the arable farmers see a combination and balance of all principles as important in the future. Arable farmers see the soil as most important and other values as complementary. All groups of experienced farmers were worried about new converters, who seem to stick to the minimum values, as a threat to their profession. All participants seem to have the feeling to be part of the good guys and are being recognised by society in that way. They are proud of their profession and the sector. For the continuation of the sector a clear distinction from conventional agriculture is needed, but they are not afraid that conventional moves in the direction of organic. For the future, steady development and growth is preferred above fast growth. Others should also get the chance and time to develop in the way they did, but the new converters should not decrease the credibility of organic. Therefore, acceptable minimum rules should do justice to the values held by the sector as a whole

    Small Molecule LC-MS/MS Fragmentation Data Analysis and Application to Siderophore Identification

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    Rapid developments in tandem liquid chromatography-mass spectrometry (LC-MS/MS) have created wide interest in applications for the analysis of small molecule mixtures. MS/MS spectra can contain rich structural information, but because of the structural diversity of small molecules and different data acquisition methods, analysis algorithms and workflows frequently need to be tailored to individual research questions. This chapter shows how MATLAB can be used for LC-MS/MS-based structural characterization of small molecules. Starting with the import of raw data, ways for visualization and the creation of graphical user interfaces (GUIs) for individual applications are demonstrated. A selection of frequently used algorithms for pre-processing and data analysis is reviewed in context of their MATLAB implementation. The approaches are then tailored and applied to the analysis of iron-binding peptides (peptidic siderophores) by high-resolution LC-MS/MS. The method uses a database with siderophore structures to exploit prior knowledge about siderophore structural diversity for the interpretation of MS/MS spectra from known and new siderophores

    Konsum ökologischer Milch aus gesundheitlichen Gründen - Eine qualitative Erhebung auf deutschen Demeter Milchviehbetrieben und bei ihren Kunden

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    Supposedly beneficial nutritional compositions were found in organic milk. Studies report that the consumption of organic milk products affects health eg. prevention of eczema in children. Single cases describe a better digestibility of organic milk for consumers suffering from diverse atopic disorders and food allergies. To clarify whether this is a real phenomenon, a survey in combination with interviews was carried out on bio-dynamic milk farms and with affected consumers in Germany. The results show that there are consumers which are buying fresh bio-dynamic raw milk because of a better personal digestibility

    Radio Emission Signatures in the Crab Pulsar

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    Our high time resolution observations of individual pulses from the Crab pulsar show that both the time and frequency signatures of the interpulse are distinctly different from those of the main pulse. Main pulses can occasionally be resolved into short-lived, relatively narrow-band nanoshots. We believe these nanoshots are produced by soliton collapse in strong plasma turbulence. Interpulses at centimeter wavelengths are very different. Their dynamic spectrum contains regular, microsecond-long emission bands. We have detected these bands, proportionately spaced in frequency, from 4.5 to 10.5 GHz. The bands cannot easily be explained by any current theory of pulsar radio emission; we speculate on possible new models.Comment: 26 pages, 10 figures, to appear in Ap

    L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling.

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    During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits. How such a system works in coordination is not well understood. Cross-regulatory interactions between different signalling pathways and redundancy between them can increase precision and fidelity of guidance systems. Immunoglobulin superfamily proteins of the NCAM and L1 families couple specific substrate recognition and cell adhesion with the activation of receptor tyrosine kinases. Thus it has been shown that L1CAM-mediated cell adhesion promotes the activation of the EGFR (erbB1) from Drosophila to humans. Here we explore the specificity of the molecular interaction between L1CAM and the erbB receptor family. We show that L1CAM binds physically erbB receptors in both heterologous systems and the mammalian developing brain. Different Ig-like domains located in the extracellular part of L1CAM can support this interaction. Interestingly, binding of L1CAM to erbB enhances its response to neuregulins. During development this may synergize with the activation of erbB receptors through L1CAM homophilic interactions, conferring diffusible neuregulins specificity for cells or axons that interact with the substrate through L1CAM

    Citrus/Cydonia Comp. Can Restore the Immunological Balance in Seasonal Allergic Rhinitis-Related Immunological Parameters In Vitro

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    In two in vitro studies, we examined the immunological (pathways of the) effects of Citrus/Cydonia comp. from, respectively, a healthy and an allergic donor; peripheral blood mononuclear cells (PBMCs) were isolated out of peripheral blood and analyzed in vitro after polyclonal stimulation of T-cells. The differentiation capacity and the influence with regard to Th1 (IFN-γ) and Th2 (IL-5) cells were examined. Citrus/Cydonia comp. has a selective effect on the differentiation of T-cells by producing relatively more IL-10 than IL-12. By that, it also seems to have an effect on the induction of regulatory (IL-10 producing) T-cell subsets. It is in vitro capable of neutralizing (to some extent) the changes, characteristic to allergic rhinitis, with regard to the maturation, differentiation, and activity of the immune system. Thus, Citrus/Cydonia comp. can potentially restore the disturbed immune state of rhinitis patients, which essentially could be sufficient to make allergic symptoms disappear permanently

    Continuous monitoring of the boundary-layer top with lidar

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    International audienceContinuous lidar observations of the top height of the boundary layer (BL top) have been performed at Leipzig (51.3° N, 12.4° E), Germany, since August 2005. The results of measurements taken with a compact, automated Raman lidar over a one-year period (February 2006 to January 2007) are presented. Four different methods for the determination of the BL top are discussed. The most promising technique, the wavelet covariance algorithm, is improved by implementing some modifications so that an automated, robust retrieval of BL depths from lidar data is possible. Three case studies of simultaneous observations with the Raman lidar, a vertical-wind Doppler lidar, and accompanying radiosonde profiling of temperature and humidity are discussed to demonstrate the potential and the limits of the four lidar techniques at different aerosol and meteorological conditions. The lidar-derived BL top heights are compared with respective values derived from predictions of the regional weather forecast model COSMO of the German Meteorological Service. The comparison shows a general underestimation of the BL top by about 20% by the model. The statistical analysis of the one-year data set reveals that the seasonal mean of the daytime maximum BL top is 1400 m in spring, 1800 m in summer, 1200 m in autumn, and 800 m in winter at the continental, central European site. BL top typically increases by 100?300 m per hour in the morning of convective days

    Time-Frequency Analysis of Rocket Nozzle Wall Pressures During Start-up Transients

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    Surveys of the fluctuating wall pressure were conducted on a sub-scale, thrust- optimized parabolic nozzle in order to develop a physical intuition for its Fourier-azimuthal mode behavior during fixed and transient start-up conditions. These unsteady signatures are driven by shock wave turbulent boundary layer interactions which depend on the nozzle pressure ratio and nozzle geometry. The focus however, is on the degree of similarity between the spectral footprints of these modes obtained from transient start-ups as opposed to a sequence of fixed nozzle pressure ratio conditions. For the latter, statistically converged spectra are computed using conventional Fourier analyses techniques, whereas the former are investigated by way of time-frequency analysis. The findings suggest that at low nozzle pressure ratios -- where the flow resides in a Free Shock Separation state -- strong spectral similarities occur between fixed and transient conditions. Conversely, at higher nozzle pressure ratios -- where the flow resides in Restricted Shock Separation -- stark differences are observed between the fixed and transient conditions and depends greatly on the ramping rate of the transient period. And so, it appears that an understanding of the dynamics during transient start-up conditions cannot be furnished by a way of fixed flow analysis

    CHECKLIST USE FOR ASSESSMENT OF SATISFACTION WITH TRANS-TIBIAL PROSTHESES

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    Objective: To assess satisfaction of prosthesis users with their prostheses, and the problems they experience with the residual limb, using a checklist, in order to evaluate potential benefits of checklist use and to summarize issues and problems with the prosthesis and/or residual limb presented by prosthesis users.Design: Cross-sectional study.Subjects: Participants were adult trans-tibial prosthesis users (n = 82) and certified prosthetist orthotist (n = 19) experienced in fitting lower-limb prostheses.Methods: Prosthesis users reported their reasons for consultation and factors concerning prosthesis (dis)satisfaction and residual limb problems, using a checklist. Checklist use was evaluated by certified prosthetist orthotists and prosthesis users and the significance of evaluation scores was determined.Results: Checklist use identified 126 issues/problems, most of which concerned prosthesis fit (33%) and pressure points on the residual limb skin (26%). Evaluation scores were significantly higher than neutral regarding the checklist helping the certified prosthetist orthotist to gather more information and to make clear with which issues the prosthesis user was dissatisfied. Prosthesis users reported that checklist use made them feel more understood by the certified prosthetist orthotist.Conclusion: Checklist use in the assessment of trans-tibial prostheses is beneficial in identifying factors related to dissatisfaction, and improves the quality of certified prosthetist orthotists' consultation. The implementation of checklist use is, however, challenging.</p

    The spectral aerosol extinction monitoring system (SÇMS): Setup, observational products, and comparisons

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    The Spectral Aerosol Extinction Monitoring System (SÇMS) is presented that allows us to continuously measure the spectral extinction coefficient of atmospheric aerosol particles along an approximately 2.7 km long optical path at 30–50 m height above ground in Leipzig (51.3° N, 12.4° E), Germany. The fully automated instrument measures the ambient aerosol extinction coefficients from 300 to 1000 nm. The main goal of (SÇMS) observations are long-term studies of the relationship between particle extinction and relative humidity from below 40% to almost 100%. The setup is presented and observations (a case study and statistical results for 2009) are discussed in terms of time series of 550 nm particle optical depth, Ångström exponent, and particle size distribution retrieved from the spectrally resolved extinction. The SǼMS measurements are compared with simultaneously performed EARLINET (European Aerosol Research Lidar Network) lidar, AERONET (Aerosol Robotic Network) sun photometer, and in situ aerosol observations of particle size distribution and related extinction coefficients on the roof of our institute. Consistency between the different measurements is found, which corroborates the quality of the SǼMS observations. Statistical results of a period of 1 yr (2009) show mode extinction values of 0.09 km−1 (SÇMS), 0.075 km−1 (AERONET), and 0.03 km−1 (in situ). Ångström exponents for this period are 0.19 (390–880 nm,(SÇMS) and 1.55 (440–870 nm, AERONET)
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